Description

2-(2-Isopropoxyphenyl)-6,8-Dimethylquinoline-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced synthesis. This compound matters because it serves as a critical building block for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries seeking to introduce specific quinoline-based functionalities into their target molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzyme pathways where the quinoline scaffold is pharmacologically active.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, such as herbicides and fungicides, leveraging its structural properties for enhanced efficacy.
• Material Science Research: Employed in the development of organic electronic materials, including OLEDs and sensors, due to the electron-transport properties of the quinoline core.
• Ligand and Catalyst Development: Serves as a starting material for creating complex chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Fluorescent Probe Synthesis: Utilized to construct fluorescent markers and probes for biochemical assays and diagnostic imaging applications.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific acyl chloride functionality.

Basic Information

Product Name	2-(2-Isopropoxyphenyl)-6,8-Dimethylquinoline-4-Carbonyl Chloride
CAS No.	1160263-01-3
Molecular Formula	C21H20ClNO2
Molecular Weight	353.84 g/mol
Synonyms	6,8-Dimethyl-2-(2-propan-2-yloxyphenyl)quinoline-4-carbonyl chloride; 2-(2-Isopropoxyphenyl)-6,8-dimethyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 6,8-dimethyl-2-[2-(1-methylethoxy)phenyl]-; 1160263-01-3; 2-(2-Isopropoxyphenyl)-6,8-dimethylquinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 2-(2-Isopropoxyphenyl)-6,8-Dimethylquinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.