Description

2-(2,5-Dimethylphenyl)-6-Methylquinoline-4-Carbonyl Chloride is a high-value, reactive chemical intermediate belonging to the quinoline family, specifically designed for advanced synthesis. Its core value lies in its role as a versatile acyl chloride building block, enabling the efficient introduction of a complex quinoline moiety into target molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides, herbicides, and fungicides, where the quinoline scaffold can impart specific biological activity.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as ligands for catalysts, organic semiconductors, or fluorescent dyes and sensors.
• Chemical Biology Probes: Employed in the development of chemical probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical raw material for fine chemical manufacturers and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-(2,5-Dimethylphenyl)-6-Methylquinoline-4-Carbonyl Chloride
CAS No.	1160253-49-5
Molecular Formula	C20H16ClNO
Molecular Weight	321.80 g/mol
Synonyms	6-Methyl-2-(2,5-dimethylphenyl)quinoline-4-carbonyl chloride; 2-(2,5-Dimethylphenyl)-6-methyl-4-quinolinecarbonyl chloride; 4-Quinolinecarbonyl chloride, 2-(2,5-dimethylphenyl)-6-methyl-; 2,5-Dimethyl-6-methylquinoline-4-carbonyl chloride (common name variant); Quinoline-4-carbonyl chloride derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(2,5-Dimethylphenyl)-6-Methylquinoline-4-Carbonyl Chloride is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC), identity (by IR and NMR), and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be handled under inert atmosphere (e.g., nitrogen or argon) when opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.