Description

6-Methyl-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride is a high-purity, reactive chemical intermediate essential for advanced organic synthesis. Its core value lies in its role as a key building block for constructing complex heterocyclic compounds, particularly in the development of active pharmaceutical ingredients (APIs) and functional materials. This product is critically needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce the quinoline scaffold into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases, cancer, and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of advanced fungicides, herbicides, and insecticides that leverage the biological activity of the quinoline moiety.
• Material Science Research: Serves as a building block for creating organic light-emitting diodes (OLEDs), fluorescent dyes, and other functional organic materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: A valuable reagent for university laboratories and CROs (Contract Research Organizations) engaged in medicinal chemistry and heterocyclic chemistry projects.
• Scale-up & Process Chemistry: Suitable for process optimization and kilogram-scale production under controlled GMP-like conditions for critical pharmaceutical pipelines.

Basic Information

Product Name	6-Methyl-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride
CAS No.	1160253-43-9
Molecular Formula	C19H14ClNO
Molecular Weight	307.77 g/mol
Synonyms	2-(p-Tolyl)-6-methylquinoline-4-carbonyl chloride; 4-Quinolinecarbonyl chloride, 6-methyl-2-(4-methylphenyl)-; 6-Methyl-2-(p-tolyl)quinoline-4-carboxylic acid chloride; 2-(4-Methylphenyl)-6-methylquinoline-4-carbonyl chloride; 6-Methyl-2-(4-methylphenyl)-4-quinolinecarbonyl chloride; 4-Carboxy-6-methyl-2-(p-tolyl)quinoline chloride; p-Tolyl-6-methylquinoline-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 6-Methyl-2-(4-Methylphenyl)Quinoline-4-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with global regulatory frameworks, including ICH guidelines and REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.