Description

1'-Acetyl-6-Bromospiro[Indoline-3,4'-Piperidin]-2-One is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly within central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially those targeting complex biological pathways.
• Medicinal Chemistry Research: Used as a core scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Protease Inhibitor Synthesis: The spirocyclic indoline-piperidine structure is relevant for constructing molecules that may interact with enzyme active sites.
• Ligand Development for CNS Targets: Employed in the synthesis of potential ligands for neurological receptors and transporters.
• Chemical Biology Probes: Useful for creating specialized molecular tools to study biological processes and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	1'-Acetyl-6-Bromospiro[Indoline-3,4'-Piperidin]-2-One
CAS No.	1160248-50-9
Molecular Formula	C15H17BrN2O2
Molecular Weight	337.21 g/mol
Synonyms	6-Bromo-1'-acetylspiro[indoline-3,4'-piperidin]-2-one; 1'-Acetyl-6-bromospiro[indoline-3,4'-piperidine]-2-one; 6-Bromo-1'-acetyl-2-oxospiro[indoline-3,4'-piperidine]; Spiro[indoline-3,4'-piperidine]-2-one, 1'-acetyl-6-bromo-; 1160248-50-9; 1'-Acetyl-6-bromo-2-oxospiro[indoline-3,4'-piperidine]; 6-Bromospiro[indoline-3,4'-piperidin]-2-one, 1'-acetyl derivative
EINECS	Contact for details

Quality Control

Our 1'-Acetyl-6-Bromospiro[Indoline-3,4'-Piperidin]-2-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research applications. We provide comprehensive analytical data including HPLC purity, NMR (1H & 13C), and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are available for every batch and provided upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.