Description

2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a key synthetic building block in the development of novel active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex heterocyclic compounds targeting central nervous system and metabolic disorders.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, particularly those with spirocyclic or fused heterocyclic structures.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• API Development: Serves as a building block for the final construction of Active Pharmaceutical Ingredients (APIs) targeting neurological and psychiatric conditions.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for studying synthetic methodologies and the properties of complex nitrogen-oxygen heterocycles.

Basic Information

Product Name	2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-5-Carboxylic Acid
CAS No.	1160247-96-0
Molecular Formula	C14H15NO3
Molecular Weight	245.27 g/mol
Synonyms	Spiro[Indoline-3,4'-Pyran]-5-Carboxylic Acid, 2',3',5',6'-Tetrahydro-; 2',3',5',6'-Tetrahydrospiro[indoline-3,4'-pyran]-5-carboxylic acid; Tetrahydrospiropyran-indole-5-carboxylic acid; 5-Carboxy-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]; CAS 1160247-96-0
EINECS	Contact for details

Quality Control

Every batch of 2',3',5',6'-Tetrahydrospiro[Indoline-3,4'-Pyran]-5-Carboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for pharmaceutical R&D and pre-clinical development. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.