Description

tert-Butyl 1,2,3,5-Tetrahydrospiro[Benzo[C]-Azepine-4,4'-Piperidine]-1'-Carboxylate CAS NO 1160247-89-1 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic structure. This compound is of critical importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutics. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) with potential therapeutic effects.
• API Synthesis: A key scaffold in the production of Active Pharmaceutical Ingredients (APIs) for potential treatments of CNS disorders, such as depression, anxiety, or schizophrenia.
• Chemical Biology Probes: Utilized in the development of molecular probes to study specific biological targets and receptor interactions.
• Process Chemistry & Scale-Up: Employed in the optimization and pilot-scale production of developmental drugs before commercial manufacturing.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	tert-Butyl 1,2,3,5-Tetrahydrospiro[Benzo[C]-Azepine-4,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-89-1
Molecular Formula	C20H28N2O2
Molecular Weight	328.45 g/mol
Synonyms	1'-Boc-spiro[benzo[c]azepine-4,4'-piperidine]; tert-Butyl 1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylate; 1,2,3,5-Tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[benzo[c]azepine-4,4'-piperidine]-1'-carboxylic acid, 1,2,3,5-tetrahydro-, 1,1-dimethylethyl ester; 1160247-89-1; BOC-Spiro[benzo[c]azepine-4,4'-piperidine]; 1'-Boc-1,2,3,5-tetrahydrospiro[benzo[c]azepine-4,4'-piperidine]
EINECS	Contact for details

Quality Control

Our tert-Butyl 1,2,3,5-Tetrahydrospiro[Benzo[C]-Azepine-4,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.