Description

tert-Butyl 7-Bromo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate CAS NO 1160247-38-0 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially those targeting complex receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Protease Inhibitor Development: The spirocyclic indene-piperidine structure is relevant for designing inhibitors of various enzymatic targets.
• Ligand Synthesis for CNS Targets: Employed in the development of ligands for neurological targets such as sigma receptors or ion channels.
• Chemical Biology Probes: Useful for creating tool compounds to study biological pathways and protein function.
• Custom Synthesis Building Block: Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.

Basic Information

Product Name	tert-Butyl 7-Bromo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	1160247-38-0
Molecular Formula	C18H24BrNO2
Molecular Weight	366.30 g/mol
Synonyms	1'-Boc-7-Bromo-2,3-dihydrospiro[indene-1,4'-piperidine]; 7-Bromo-1,2-dihydrospiro[3H-indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 7-bromo-1,2-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 7-Bromo-2,3-dihydro-1H-spiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Boc-7-Bromo-spiro[indenepiperidine]; 1160247-38-0; 7-Bromo-spiro[indane-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 7-Bromo-2,3-Dihydrospiro[Indene-1,4'-Piperidine]-1'-Carboxylate adheres to stringent quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP-compliant applications for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.