Description

tert-Butyl 3-(Aminomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate CAS NO 1160246-99-0 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and oxa-aza bicyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting neurological receptors.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• API Synthesis: Serves as a key chiral building block for constructing sophisticated molecular architectures in final active pharmaceutical ingredients.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Chemical Biology Probes: Utilized in the development of tool compounds for investigating biological pathways and target validation.
• Custom Synthesis: A starting material for bespoke chemical synthesis services catering to specific client requirements in life sciences.

Basic Information

Product Name	tert-Butyl 3-(Aminomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate
CAS No.	1160246-99-0
Molecular Formula	C15H28N2O3
Molecular Weight	284.40 g/mol
Synonyms	9-Boc-3-(aminomethyl)-2-oxa-9-azaspiro[5.5]undecane; tert-Butyl 3-(aminomethyl)-2-oxa-9-azaspiro[5.5]undecane-9-carboxylate; 2-Oxa-9-azaspiro[5.5]undecane-9-carboxylic acid, 3-(aminomethyl)-, 1,1-dimethylethyl ester; 3-(Aminomethyl)-2-oxa-9-azaspiro[5.5]undecane-9-carboxylic acid tert-butyl ester; Boc-Protected 3-aminomethyl-2-oxa-9-azaspiro[5.5]undecane; 1160246-99-0
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Aminomethyl)-2-Oxa-9-Azaspiro[5.5]Undecane-9-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.