Description

tert-Butyl 3-Cyano-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers requiring high-purity building blocks for complex molecule construction. The product's unique scaffold offers versatile functionalization points for medicinal chemists developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its spirocyclic core.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs).
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Chemical Biology Probes: Utilized in the development of tool compounds for target validation and biochemical pathway studies.
• Academic Research: Employed in university and institutional labs for methodological development in organic synthesis.

Basic Information

Product Name	tert-Butyl 3-Cyano-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate
CAS No.	1160246-93-4
Molecular Formula	C14H22N2O3
Molecular Weight	266.34 g/mol
Synonyms	8-Boc-3-cyano-1-oxa-8-azaspiro[4.5]decane; tert-Butyl 3-cyano-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-cyano-, 1,1-dimethylethyl ester; 3-Cyano-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; Boc-1-oxa-8-azaspiro[4.5]decane-3-carbonitrile; 1160246-93-4; 8-N-Boc-3-cyano-1-oxa-8-azaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-Cyano-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.