Description

3-Fmoc-Aminomethyl-Piperidine Hcl is a key protected amino acid derivative and a vital building block in modern organic synthesis. Its primary value lies in providing a sterically hindered, base-labile Fmoc-protected amine functionality, which is essential for constructing complex molecular architectures. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in peptide synthesis and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected intermediate for incorporating the aminomethyl-piperidine moiety into peptide sequences, enabling the synthesis of novel peptide therapeutics and research tools.
• Medicinal Chemistry & Drug Discovery: Used as a versatile scaffold and building block for the design and synthesis of small molecule libraries targeting various disease pathways, particularly in central nervous system (CNS) and oncology research.
• Combinatorial Chemistry: Serves as a valuable input for generating diverse compound libraries via parallel synthesis techniques to accelerate lead identification and optimization.
• Protecting Group Strategy: The Fmoc group allows for orthogonal deprotection under mild basic conditions (e.g., piperidine), facilitating complex multi-step syntheses of sensitive molecules.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged molecules for studying biological interactions, enzyme mechanisms, and cellular processes.
• Process Chemistry & API Development: Used in the development and scale-up of synthetic routes for Active Pharmaceutical Ingredients (APIs) that contain the piperidine structural motif.

Basic Information

Product Name	3-Fmoc-Aminomethyl-Piperidine Hcl
CAS No.	1159826-46-6
Molecular Formula	C22H26N2O2 • HCl
Molecular Weight	386.92 g/mol (Free base: 350.46)
Synonyms	1-[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethyl-3-piperidinecarboxylic acid hydrochloride; 3-[(Fmoc-amino)methyl]piperidine hydrochloride; 3-(Fmoc-aminomethyl)piperidine HCl; 1-N-Fmoc-3-aminomethylpiperidine hydrochloride; 3-(Aminomethyl)-1-piperidinecarboxylic acid 9H-fluoren-9-ylmethyl ester hydrochloride; N-[(3-Piperidinyl)methyl]-9H-fluoren-9-ylmethoxycarboxamide hydrochloride; Fmoc-3-Amp(Pip)-OH • HCl
EINECS	Contact for details

Quality Control

Every batch of 3-Fmoc-Aminomethyl-Piperidine Hcl is produced and tested under a strict quality management system. We ensure compliance with high-purity standards typical for advanced pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.