Description

2-Aminomethyl-1-n-Boc-1,2,3,4-Tetrahydroquinoline Hcl is a protected amine derivative of the tetrahydroquinoline scaffold, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of the aminomethyl-tetrahydroquinoline moiety into complex molecules, which is essential for developing novel pharmaceutical candidates. This high-purity intermediate is specifically needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of bioactive compounds targeting central nervous system and oncological pathways.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in neuropharmacology and oncology.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore novel drug-like chemical space.
• Peptidomimetic Synthesis: Employed in the construction of constrained peptide analogs and peptidomimetics due to its rigid tetrahydroquinoline core.
• Ligand and Probe Development: Serves as a precursor for creating chemical probes and high-affinity ligands for biological target validation.
• Scale-Up Process Chemistry: Suitable for use in kilo-lab and pilot plant scale synthesis under current Good Manufacturing Practice (cGMP) guidelines for non-clinical and clinical trial material production.

Basic Information

Product Name	2-Aminomethyl-1-n-Boc-1,2,3,4-Tetrahydroquinoline Hcl
CAS No.	1159826-22-8
Molecular Formula	C₁₆H₂₃ClN₂O₂
Molecular Weight	310.82 g/mol
Synonyms	1,2,3,4-Tetrahydroquinoline, 2-(aminomethyl)-1-[(1,1-dimethylethoxy)carbonyl]-, hydrochloride (1:1); 1-N-Boc-2-aminomethyl-1,2,3,4-tetrahydroquinoline hydrochloride; tert-Butyl 2-(aminomethyl)-1,2,3,4-tetrahydroquinoline-1-carboxylate hydrochloride; 2-(Aminomethyl)-N-Boc-1,2,3,4-tetrahydroquinoline HCl; Boc-ATQ-HCl; N-Boc-2-aminomethyltetrahydroquinoline hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 2-Aminomethyl-1-n-Boc-1,2,3,4-Tetrahydroquinoline Hcl is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing to ensure compliance with industry standards. Comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry, are documented. Certificates of Analysis (COA) are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.