Description

1-Cbz-3-Aminopyrrolidine Hydrochloride is a high-purity, protected amine building block essential for modern pharmaceutical and agrochemical research. This compound serves as a critical intermediate in the synthesis of complex molecules, enabling the development of new active ingredients. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Peptidomimetic Chemistry: Used to introduce constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators with specific chiral centers.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tags for studying enzyme function.
• Ligand Development: Useful for creating novel ligands for catalysis and asymmetric synthesis in fine chemical manufacturing.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects.

Basic Information

Product Name	1-Cbz-3-Aminopyrrolidine Hydrochloride
CAS No.	1159822-27-1
Molecular Formula	C12H17ClN2O2
Molecular Weight	256.73 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-aminopyrrolidine hydrochloride; 3-Amino-1-Cbz-pyrrolidine hydrochloride; 1-N-Cbz-3-aminopyrrolidine HCl; (3-Aminopyrrolidin-1-yl)(phenyl)methanone hydrochloride; Benzyl 3-aminopyrrolidine-1-carboxylate hydrochloride; 1-Carbobenzoxy-3-aminopyrrolidine hydrochloride; N-Cbz-3-Aminopyrrolidine hydrochloride; 3-Amino-1-(phenylmethoxy)carbonylpyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-Cbz-3-Aminopyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for research and development. Certificates of Analysis (COA) detailing specifications such as assay, chiral purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.