Description

tert-Butyl 3-(4-Bromophenyl)-2-((Methylamino)Methyl)Propanoate Hydrochloride is a high-purity organic building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its functionalized structure, which incorporates a bromophenyl group, a protected carboxylic acid, and a methylamino moiety, making it a versatile synthon for medicinal chemistry and advanced material synthesis. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization due to its modifiable bromine and amine functional groups.
• Agrochemical Synthesis: Serves as a precursor for developing advanced crop protection agents and herbicides.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal-catalyzed coupling reactions.
• Peptidomimetic Synthesis: The tert-butyl ester and amino-methyl side chain make it useful for constructing non-natural amino acid derivatives.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring complex, multi-functional aromatic compounds.

Basic Information

Item	Details
Product Name	tert-Butyl 3-(4-Bromophenyl)-2-((Methylamino)Methyl)Propanoate Hydrochloride
CAS No.	1159822-24-8
Molecular Formula	C15H22BrNO2 • HCl
Molecular Weight	364.71 g/mol (Free base: 328.25 g/mol)
Synonyms	3-(4-Bromophenyl)-2-[(methylamino)methyl]propanoic acid tert-butyl ester hydrochloride; 2-[(Methylamino)methyl]-3-(4-bromophenyl)propionic acid tert-butyl ester HCl; tert-Butyl 2-((methylamino)methyl)-3-(p-bromophenyl)propionate hydrochloride; 1159822-24-8; Methylamino-methyl-bromophenyl-propanoate tert-butyl ester HCl; p-Bromo-α-[(methylamino)methyl]benzenepropanoic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(4-Bromophenyl)-2-((Methylamino)Methyl)Propanoate HCl is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.