Description

4-Oxo-5-Trifluoromethyl-1,4-Dihydro-Quinoline-3-Carboxylic Acid Ethyl Ester is a high-value, fluorinated quinoline derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique physicochemical properties essential for developing novel bioactive compounds. This product is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on creating new drug candidates, particularly in therapeutic areas requiring enhanced metabolic stability and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinolone and fluoroquinolone-based drug candidates.
• Agrochemical Research: Used in developing advanced active ingredients for crop protection products, leveraging the bioactivity of the quinoline core.
• Material Science Precursor: Serves as a starting material for synthesizing specialized fluorinated organic compounds used in electronic materials or liquid crystals.
• Chemical Biology Probes: Utilized in research to create fluorescent tags or molecular probes due to the inherent photophysical properties of the quinoline structure.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and medicinal chemistry within university and CRO laboratories.

Basic Information

Product Name	4-Oxo-5-Trifluoromethyl-1,4-Dihydro-Quinoline-3-Carboxylic Acid Ethyl Ester
CAS No.	1159590-65-4
Molecular Formula	C₁₃H₁₀F₃NO₃
Molecular Weight	285.22 g/mol
Synonyms	Ethyl 4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate; 5-Trifluoromethyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; 1,4-Dihydro-4-oxo-5-(trifluoromethyl)-3-quinolinecarboxylic acid ethyl ester; 5-Trifluoromethyl-4-quinolone-3-carboxylic acid ethyl ester; Ethyl 5-trifluoromethyl-4-oxoquinoline-3-carboxylate; Quinoline-3-carboxylic acid, 1,4-dihydro-4-oxo-5-(trifluoromethyl)-, ethyl ester; CAS 1159590-65-4
EINECS	Contact for details

Quality Control

Our 4-Oxo-5-Trifluoromethyl-1,4-Dihydro-Quinoline-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect this light-sensitive material from moisture and atmospheric contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.