Description

1-Pyrrolidinedodecanoic Acid, 2-[[Bis(4-Methoxyphenyl)Phenylmethoxy]Methyl]-4-Hydroxy-λ-Oxo-, (2S,4R)-, Compd. With N,n-Diethylethanamine (1:1) is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate, specifically a salt form of the active pharmaceutical ingredient (API) doravirine. This compound matters for its critical role in the synthesis of modern antiviral medications, offering a defined stereochemistry essential for therapeutic efficacy. It is primarily needed by pharmaceutical R&D laboratories and manufacturers specializing in the production of HIV/AIDS treatments, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of the antiretroviral drug Doravirine (MK-1439).
• Antiviral Drug Research: Used in the discovery and development of novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and starting material for process optimization and manufacturing scale-up.
• Analytical Standard: Employed as a high-purity standard for HPLC, LC-MS, and NMR analysis in quality control laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) engaged in API production for global markets.
• Regulatory Submissions: Provides a characterized material for use in stability studies and regulatory filing dossiers (e.g., DMF, CMC sections).

Basic Information

Product Name	1-Pyrrolidinedodecanoic Acid, 2-[[Bis(4-Methoxyphenyl)Phenylmethoxy]Methyl]-4-Hydroxy-λ-Oxo-, (2S,4R)-, Compd. With N,n-Diethylethanamine (1:1)
CAS No.	1159408-71-5
Molecular Formula	C44H61NO7 • C6H15N
Molecular Weight	Contact for details
Synonyms	Doravirine Diethylamine Salt; Doravirine DEA Salt; (2S,4R)-2-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-1-oxo-1-pyrrolidinedodecanoic Acid Compound with N,N-Diethylethanamine (1:1); MK-1439 Diethylamine Salt; MK-1439 DEA Salt; PNU-142721 Diethylamine Salt; NNRTI Intermediate DEA Salt; 1-Oxo-1-pyrrolidinedodecanoic acid, 2-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-4-hydroxy-, (2S,4R)-, compd. with N,N-diethylethanamine (1:1)
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with pharmaceutical industry standards. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and LC-MS to confirm identity, purity, and stereochemical integrity. Certificates of Analysis (COA) are available upon request, detailing comprehensive specifications. We support compliance with ICH guidelines for stability and impurity profiling, making this material suitable for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Purity (HPLC, Total)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.