Description

3-Bromo-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1159010-96-4. This compound is a critical building block in modern medicinal chemistry, valued for its unique fused heterocyclic structure which serves as a versatile scaffold for drug discovery. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the design of new chemical entities.
• Kinase Inhibitor Development: The naphthyridine core is a privileged structure in the design of potent and selective kinase inhibitors for cancer therapy.
• CNS Drug Discovery: Employed in the research and development of compounds targeting neurological disorders.
• Chemical Biology Probes: Serves as a starting material for creating tool compounds to study biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the pharmaceutical industry's outsourced R&D and production needs.

Basic Information

Product Name	3-Bromo-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride
CAS No.	1159010-96-4
Molecular Formula	C8H10BrClN2
Molecular Weight	249.53 g/mol
Synonyms	3-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride; 3-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine HCl; 1,6-Naphthyridine, 3-bromo-5,6,7,8-tetrahydro-, hydrochloride; 3-Bromo-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Bromo-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.