Description

2-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-7-Yl)Acetic Acid is a high-purity, protected amino acid derivative featuring a tetrahydroisoquinoline scaffold and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical pharmaceutical intermediate valued for its role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for developing new drug candidates, including protease inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological disorders and enzymatic pathways.
• Peptide & Peptidomimetic Synthesis: Used to incorporate the tetrahydroisoquinoline moiety into peptide chains, enhancing metabolic stability and biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Protease Inhibitor Development: Integral in creating inhibitors for various proteases, with applications in antiviral, anticancer, and anti-inflammatory therapeutics.
• Chemical Biology Probes: Utilized in the development of probes and labeled compounds for studying biological mechanisms and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of APIs (Active Pharmaceutical Ingredients) and advanced intermediates under cGMP conditions.

Basic Information

Product Name	2-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-7-Yl)Acetic Acid
CAS No.	1158755-34-0
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34 g/mol
Synonyms	7-Carboxymethyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-1,2,3,4-tetrahydroisoquinoline-7-acetic acid; 2-(2-((tert-Butoxy)carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetic acid; Boc-Tic(7-CH2COOH)-OH; (2-((tert-Butoxycarbonyl)-1,2,3,4-tetrahydro-7-isoquinolyl)acetic acid; 2-(2-(Boc)-1,2,3,4-tetrahydroisoquinolin-7-yl)acetic acid; 1158755-34-0
EINECS	Contact for details

Quality Control

Our 2-(2-(tert-Butoxycarbonyl)-1,2,3,4-Tetrahydroisoquinolin-7-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccant in the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.