Description

1,8-Diazaspiro[4.5]Decan-2-One is a high-purity, nitrogen-containing spirocyclic organic compound with the CAS registry number 1158749-93-9. This versatile heterocyclic building block is valued for its rigid, three-dimensional structure, which is crucial for modulating the physicochemical properties and biological activity of advanced molecules. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for use in medicinal chemistry and as a key intermediate in the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the research and development of new drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Scaffold: Used to introduce conformational restraint and improve the potency, selectivity, and metabolic stability of lead compounds.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology Probe Development: Employed in the synthesis of tool compounds for studying enzyme function and biological pathways.
• Ligand Synthesis for Catalysis: Utilized in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: Supplied to universities and CROs (Contract Research Organizations) for fundamental research and custom synthesis projects.

Basic Information

Product Name	1,8-Diazaspiro[4.5]Decan-2-One
CAS No.	1158749-93-9
Molecular Formula	C8H14N2O
Molecular Weight	154.21 g/mol
Synonyms	1,8-Diazaspiro[4.5]decan-2-one; 2-Oxo-1,8-diazaspiro[4.5]decane; 1,8-Diazaspiro[4.5]decan-2-one; Spiro[piperidine-4,2'-pyrrolidin]-3'-one; 1,8-Diaza-spiro[4.5]decan-2-one; 8-Aza-1-azaspiro[4.5]decan-2-one
EINECS	Contact for details

Quality Control

Every batch of 1,8-Diazaspiro[4.5]Decan-2-One is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and process chemistry. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications from HPLC, NMR, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.