Description

1,6-Diazaspiro[3.4]Octane-6-Carboxylic Acid, 1,1-Dimethylethyl Ester is a high-value, protected spirocyclic amine building block essential for modern pharmaceutical and agrochemical research. Its unique rigid bicyclic structure serves as a critical scaffold for constructing novel molecules with enhanced biological activity and metabolic stability. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs.
• Medicinal Chemistry Scaffold: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained spirocyclic geometry.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and protein-protein interactions.
• Peptidomimetics: Used to create conformationally restricted peptide analogs with improved bioavailability and selectivity.
• Library Synthesis: A valuable reactant for generating diverse compound libraries in high-throughput screening (HTS) programs.

Basic Information

Product Name	1,6-Diazaspiro[3.4]Octane-6-Carboxylic Acid, 1,1-Dimethylethyl Ester
CAS No.	1158749-79-1
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	tert-Butyl 1,6-diazaspiro[3.4]octane-6-carboxylate; 1,1-Dimethylethyl 1,6-Diazaspiro[3.4]octane-6-carboxylate; 6-Boc-1,6-diazaspiro[3.4]octane; 1,6-Diazaspiro[3.4]octane-6-carboxylic acid tert-butyl ester; Boc-1,6-diazaspiro[3.4]octane; Spirocyclic Amine Building Block; 1158749-79-1
EINECS	Contact for details

Quality Control

Our 1,6-Diazaspiro[3.4]Octane-6-Carboxylic Acid, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.