Description

(1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its defined stereochemistry and functional groups, which are critical for synthesizing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is essential for research and development chemists and manufacturers in the pharmaceutical industry, particularly those working on central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for APIs targeting neurological and psychiatric disorders.
• Asymmetric Synthesis: Utilized in stereoselective chemical reactions to construct complex molecules with high enantiomeric purity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic entities.
• Preclinical and Clinical Trial Material: Supplied under controlled conditions for the production of materials used in non-clinical and clinical studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	(1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine Hydrochloride
CAS No.	1156491-10-9
Molecular Formula	C9H10ClF2N
Molecular Weight	205.63 g/mol
Synonyms	(1R,2S)-rel-2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropan-1-amine hydrochloride; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamine hydrochloride; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine HCl; 2-(3,4-Difluorophenyl)cyclopropanamine hydrochloride (1R,2S)-; UNII-3V7K1K9V8P; 3V7K1K9V8P
EINECS	Contact for details

Quality Control

Our (1R,2S)-2-(3,4-Difluorophenyl)Cyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.