Description

2-Propyl-8-Trifluoromethoxyquinolin-4-Ol is a high-purity, advanced pharmaceutical intermediate belonging to the quinoline class of heterocyclic compounds. Its core value lies in its role as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. This compound is essential for research and development chemists and process scale-up teams within the global pharmaceutical and agrochemical industries. The strategic incorporation of both propyl and trifluoromethoxy substituents makes it a valuable precursor for compounds targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A key synthon in the research and commercial synthesis of new drug candidates, especially in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Research: Serves as a foundational structure for developing new generation pesticides and herbicides, leveraging the biological activity of the quinoline core.
• Chemical Biology & Proteomics: Used as a molecular scaffold or tagging agent in the design of chemical probes for studying enzyme function and protein interactions.
• Material Science Precursor: Potential use in the synthesis of organic electronic materials and ligands for catalytic complexes due to its electron-deficient aromatic system.
• Contract Research & Manufacturing (CRAM): Supplied to organizations engaged in custom synthesis and process development for client-specific projects.

Basic Information

Product Name	2-Propyl-8-Trifluoromethoxyquinolin-4-Ol
CAS No.	1154918-20-3
Molecular Formula	C₁₄H₁₄F₃NO₂
Molecular Weight	285.26 g/mol
Synonyms	8-(Trifluoromethoxy)-2-propylquinolin-4-ol; 4-Hydroxy-2-propyl-8-(trifluoromethoxy)quinoline; 2-Propyl-8-trifluoromethoxy-4-quinolinol; 4-Quinolinol, 2-propyl-8-(trifluoromethoxy)-; 1154918-20-3; Quinolin-4-ol, 2-propyl-8-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-Propyl-8-Trifluoromethoxyquinolin-4-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications and results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.