Description

tert-Butyl 6-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate is a high-purity, protected amine derivative of the tetrahydroquinoline scaffold, serving as a critical building block in advanced organic synthesis. This compound matters because it provides a versatile and reactive amino group for constructing complex molecules, enabling the development of novel pharmaceuticals and agrochemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Chemical Biology & Proteomics: Employed as a scaffold or linker for creating chemical probes, enzyme inhibitors, and molecular tags due to its reactive amino group.
• Material Science: Serves as a monomer or precursor for advanced polymers and organic electronic materials with specific optical or electronic properties.
• Academic & Contract Research: Essential for methodological development in organic chemistry and for custom synthesis projects in contract research organizations (CROs).

Basic Information

Product Name	tert-Butyl 6-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate
CAS No.	1152923-36-8
Molecular Formula	C14H18N2O2
Molecular Weight	246.31 g/mol
Synonyms	1-Boc-6-amino-1,2,3,4-tetrahydroquinoline; 6-Amino-1,2,3,4-tetrahydroquinoline-1-carboxylic acid tert-butyl ester; tert-Butyl 6-amino-1,2,3,4-tetrahydroquinoline-1-carboxylate; 1,2,3,4-Tetrahydro-6-aminoquinoline-1-carboxylic acid tert-butyl ester; 6-Amino-1-Boc-1,2,3,4-tetrahydroquinoline; Boc-6-Amino-THQ; 6-Amino-THQ-Boc; 1-N-Boc-6-amino-1,2,3,4-tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Amino-3,4-Dihydroquinoline-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with full specification data are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.