Description

8-Chloro-3-Fluoro-1,5-Naphthyridine is a high-purity, halogenated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its dual functionalization, providing distinct reactive sites for the construction of complex molecular architectures. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a critical intermediate for developing novel active ingredients, particularly in medicinal chemistry programs targeting kinase inhibitors and other biologically relevant scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, especially in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Research: Serves as a precursor for the synthesis of organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental building block for custom synthesis services catering to R&D and pilot-scale production.
• Academic Research: Utilized in university and institutional labs for methodological studies in cross-coupling and heterocyclic chemistry.

Basic Information

Product Name	8-Chloro-3-Fluoro-1,5-Naphthyridine
CAS No.	1151802-02-6
Molecular Formula	C8H4ClFN2
Molecular Weight	182.58 g/mol
Synonyms	8-Chloro-3-fluoro-1,5-naphthyridine; 1,5-Naphthyridine, 8-chloro-3-fluoro-; 3-Fluoro-8-chloro-1,5-naphthyridine; 8-Chloro-3-fluoro-[1,5]naphthyridine; 1151802-02-6; FCAS 1151802-02-6
EINECS	Contact for details

Quality Control

Our 8-Chloro-3-Fluoro-1,5-Naphthyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We are committed to meeting the stringent requirements of R&D and cGMP-compliant production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.