Description

1-Chloro-2,4-Difluoro-3-Nitrobenzene, 97% is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine, fluorine, and nitro groups on the aromatic ring, enabling precise and efficient derivatization for complex molecule construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and specialty intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, where the difluoro and nitro substituents contribute to biological activity and selectivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and organic pigments due to its reactive halogen and nitro groups.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, facilitating the creation of diverse biaryl and aniline structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it highly reactive in SNAr reactions, allowing for the introduction of various nucleophiles like amines or alkoxides.

Basic Information

Product Name	1-Chloro-2,4-Difluoro-3-Nitrobenzene, 97%
CAS No.	1151767-58-6
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	3-Nitro-1-chloro-2,4-difluorobenzene; 2,4-Difluoro-1-chloro-3-nitrobenzene; 1-Chloro-2,4-difluoro-3-nitro-benzene; Benzene, 1-chloro-2,4-difluoro-3-nitro-; 1151767-58-6
EINECS	Contact for details

Quality Control

Our 1-Chloro-2,4-Difluoro-3-Nitrobenzene, 97% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.