Description

(E)-3-(6-Fluoro-4-Hydroxy-2-Methylquinolin-3-Yl)-n-(4-Fluorophenyl)But-2-Enamide is a high-purity, fluorinated quinoline derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block or intermediate for synthesizing novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new drug candidates, particularly in oncology and central nervous system (CNS) research.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Biochemical Tool Compound: Employed in vitro and in vivo to study specific biological pathways and enzyme interactions.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Custom Synthesis: A starting material for the contract synthesis of complex, fluorinated molecules for preclinical and clinical trials.

Basic Information

Product Name	(E)-3-(6-Fluoro-4-Hydroxy-2-Methylquinolin-3-Yl)-n-(4-Fluorophenyl)But-2-Enamide
CAS No.	1150271-29-6
Molecular Formula	C20H16F2N2O2
Molecular Weight	354.35 g/mol
Synonyms	(E)-3-(6-Fluoro-4-hydroxy-2-methylquinolin-3-yl)-N-(4-fluorophenyl)but-2-enamide; 3-(6-Fluoro-4-hydroxy-2-methyl-3-quinolinyl)-N-(4-fluorophenyl)-2-butenamide; (E)-N-(4-Fluorophenyl)-3-(6-fluoro-4-hydroxy-2-methylquinolin-3-yl)but-2-enamide; 1150271-29-6; But-2-enamide, 3-(6-fluoro-4-hydroxy-2-methyl-3-quinolinyl)-N-(4-fluorophenyl)-, (E)-; Fluorinated Quinolinyl Butenamide Derivative
EINECS	Contact for details

Quality Control

Our (E)-3-(6-Fluoro-4-Hydroxy-2-Methylquinolin-3-Yl)-n-(4-Fluorophenyl)But-2-Enamide is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. All material is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.