Description

Chloro[(R)-2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl][(1R,2R)-2-(Diphenylphosphino)-1,2-Diphenylethanamine]Ruthenium(II) Tetrafluoroborate is a highly specialized, chiral ruthenium complex designed for asymmetric catalysis. This compound matters for its exceptional ability to induce high enantioselectivity in critical synthetic transformations, enabling the production of single-isomer, high-value intermediates. It is primarily needed by research and development laboratories and production facilities in the pharmaceutical and fine chemical industries for the synthesis of active pharmaceutical ingredients (APIs) and advanced chiral molecules.

Application

• Asymmetric Hydrogenation: A premier catalyst for the enantioselective reduction of prochiral olefins, ketones, and imines, a cornerstone reaction in pharmaceutical synthesis.
• Pharmaceutical Intermediate Synthesis: Enables the efficient and selective production of chiral building blocks for Active Pharmaceutical Ingredients (APIs), including β-amino acids and other bioactive compounds.
• Fine Chemical Manufacturing: Used in the synthesis of specialty chemicals, agrochemicals, and flavors & fragrances where precise stereochemical control is required.
• Methodology Development: A valuable tool for chemists in academic and industrial R&D settings exploring new catalytic asymmetric reactions.
• Process Chemistry Optimization: Employed for scaling up enantioselective transformations from laboratory to pilot plant and commercial production scales.

Basic Information

Item	Detail
Product Name	Chloro[(R)-2,2'-Bis(Diphenylphosphino)-1,1'-Binaphthyl][(1R,2R)-2-(Diphenylphosphino)-1,2-Diphenylethanamine]Ruthenium(II) Tetrafluoroborate
CAS No.	1150112-54-1
Molecular Formula	C66H54BClF4NP3Ru
Molecular Weight	1152.33 g/mol
Synonyms	RuCl[(R)-BINAP][(R,R)-DPEN]BF4; Noyori-Ikariya Catalyst (BF4 Salt); (R)-BINAP/(R,R)-DPEN Ru(II) Chloride Tetrafluoroborate; Ruthenium(II) (R)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl [(1R,2R)-2-(diphenylphosphino)-1,2-diphenylethanamine] chloride tetrafluoroborate; Asymmetric Hydrogenation Catalyst Ru-BINAP-DPEN; [RuCl((R)-binap)((R,R)-dpen)]BF4; Chiral Ruthenium Diphosphine Diamine Complex
EINECS	Contact for details

Quality Control

Every batch of our chiral ruthenium catalyst is produced and tested under strict quality control protocols to ensure consistent high performance and enantioselectivity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity, chiral purity (enantiomeric excess), and metal content. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C. This compound is moisture-sensitive (hygroscopic) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will degrade its catalytic activity.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (HPLC)	≥ 99.0% e.e.
Ruthenium Content	8.5 - 9.5 %
Solubility	Soluble in dichloromethane, methanol, DMF; slightly soluble in toluene

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.