Description

(1R,3R,5R)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid CAS NO 1148048-39-8 is a high-purity, stereochemically defined bicyclic proline derivative, serving as a critical chiral building block in advanced organic synthesis. Its rigid, constrained scaffold is essential for constructing complex molecular architectures with precise three-dimensional control, directly impacting the efficacy and selectivity of final products. This compound is primarily needed by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated peptidomimetics and conformationally restricted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Scaffold: Used to construct constrained peptide analogs that enhance metabolic stability and receptor binding affinity in drug discovery.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block to induce stereoselectivity in multi-step synthetic routes.
• Medicinal Chemistry Research: Utilized in lead optimization and structure-activity relationship (SAR) studies to explore novel chemical space.
• Process Development: Serves as a starting material or intermediate in the scale-up and commercial route development for GMP-grade APIs.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	(1R,3R,5R)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid
CAS No.	1148048-39-8
Molecular Formula	C12H19NO4
Molecular Weight	241.28 g/mol
Synonyms	(1R,3R,5R)-2-((tert-Butoxy)carbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1R,3R,5R)-2-Boc-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; (1R,3R,5R)-2-(Boc)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; Bicyclo[3.1.0]hexane-3-carboxylic acid, 2-[(1,1-dimethylethoxy)carbonyl]-2-aza-, (1R,3R,5R)-; (1R,3R,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic acid; tert-Butyl (1R,3R,5R)-3-carboxy-2-azabicyclo[3.1.0]hexane-2-carboxylate; (1R,3R,5R)-2-Azabicyclo[3.1.0]hexane-3-carboxylic acid, 2-(tert-butoxycarbonyl)-
EINECS	Contact for details

Quality Control

Our (1R,3R,5R)-2-(tert-Butoxycarbonyl)-2-Azabicyclo[3.1.0]Hexane-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided and can be tailored to meet client-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.