Description

3-[2-(Trimethylsilyl)Ethynyl]-Imidazo[1,2-A]Pyridine is a specialized organic building block featuring a fused imidazopyridine core functionalized with a trimethylsilyl-protected ethynyl group. This compound matters as a key synthetic intermediate for constructing complex heterocyclic scaffolds, offering chemists a versatile handle for further functionalization via desilylation and cross-coupling reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the discovery and development of new active ingredients, as well as by advanced material scientists exploring novel organic electronic components.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel drug candidates targeting a range of therapeutic areas, leveraging the imidazo[1,2-a]pyridine pharmacophore.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the heterocyclic structure can contribute to biological activity.
• Material Science: Acts as a building block for organic semiconductors, light-emitting diodes (OLEDs), and other functional materials due to its conjugated system and modifiable alkyne group.
• Chemical Synthesis: Employed in cross-coupling reactions (e.g., Sonogashira) and click chemistry after deprotection, enabling the construction of complex molecular architectures.
• Ligand Development: Utilized for creating novel ligands in catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-[2-(Trimethylsilyl)Ethynyl]-Imidazo[1,2-A]Pyridine
CAS No.	1148027-21-7
Molecular Formula	C13H16N2Si
Molecular Weight	228.37 g/mol
Synonyms	3-[(Trimethylsilyl)ethynyl]imidazo[1,2-a]pyridine; Imidazo[1,2-a]pyridine, 3-[2-(trimethylsilyl)ethynyl]-; 3-(2-Trimethylsilylethynyl)imidazo[1,2-a]pyridine; 3-Ethynylimidazo[1,2-a]pyridine trimethylsilyl derivative; TMS-protected 3-ethynylimidazo[1,2-a]pyridine; 3-((Trimethylsilyl)ethynyl)imidazo[1,2-a]pyridine; 1148027-21-7
EINECS	Contact for details

Quality Control

Our 3-[2-(Trimethylsilyl)Ethynyl]-Imidazo[1,2-A]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure high consistency and reliability for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.