Description

Exo-8-Boc-3-Cyano-8-Azabicyclo[3.2.1]Octane is a high-value, protected bicyclic amine building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research, serving as a key precursor in the development of novel pharmaceutical candidates. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex nitrogen-containing molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial synthon for the synthesis of tropane alkaloid analogs and other bioactive molecules targeting the central nervous system.
• Medicinal Chemistry Scaffold: Used in fragment-based drug discovery and lead optimization programs to explore new chemical space.
• Agrochemical Research: Serves as a building block for developing new crop protection agents with novel modes of action.
• Chemical Biology Probe Synthesis: Employed in the creation of molecular tools for studying biological pathways and protein function.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or starting material for stereoselective reactions due to its rigid bicyclic framework.
• Custom Synthesis & Contract Manufacturing: A key starting material for CDMOs (Contract Development and Manufacturing Organizations) producing APIs (Active Pharmaceutical Ingredients) for clinical trials.

Basic Information

Product Name	Exo-8-Boc-3-Cyano-8-Azabicyclo[3.2.1]Octane
CAS No.	1147558-40-4
Molecular Formula	C13H20N2O2
Molecular Weight	236.31 g/mol
Synonyms	8-[(tert-Butoxycarbonyl)-8-azabicyclo[3.2.1]octane-3-carbonitrile, exo-; exo-3-Cyano-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester; exo-8-Boc-3-cyano-8-azabicyclo[3.2.1]octane; tert-Butyl exo-3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylate; 8-Azabicyclo[3.2.1]octane-3-carbonitrile, 8-[(1,1-dimethylethoxy)carbonyl]-, (3-endo)- (rel-); Boc-protected 3-cyano-8-azabicyclo[3.2.1]octane (exo-); exo-Boc-3-CN-8-Azabicyclo[3.2.1]octane
EINECS	Contact for details

Quality Control

Our Exo-8-Boc-3-Cyano-8-Azabicyclo[3.2.1]Octane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.