Description

Avagacestat (BMS-708163) is a potent and selective γ-secretase inhibitor (GSI) with significant research and therapeutic interest. This compound matters for its targeted mechanism of action, which is crucial for investigating pathways related to amyloid precursor protein (APP) processing. Pharmaceutical researchers, medicinal chemists, and biotechnology companies developing treatments for Alzheimer's disease and related conditions are the primary users of this high-purity reference standard.

Application

• Pharmaceutical Research & Development: As a key reference standard in the discovery and validation of γ-secretase inhibitors for Alzheimer's disease therapy.
• Biochemical Assays: Used in in vitro and cellular assays to study Notch signaling and amyloid-beta (Aβ) peptide production.
• Mechanism of Action Studies: Critical for investigating the selectivity profile of GSIs and their effects on APP versus Notch cleavage.
• Preclinical Development: Serves as a benchmark compound in pharmacokinetic, pharmacodynamic, and toxicology studies.
• Academic Research: Utilized in universities and research institutes for fundamental studies on neurodegenerative disease pathways.
• Quality Control & Analytical Standards: Employed as a certified reference material (CRM) for HPLC, LC-MS, and NMR method development and validation.

Basic Information

Product Name	Avagacestat (BMS-708163)
CAS No.	1146699-66-2
Molecular Formula	C19H19F2N5O3S
Molecular Weight	447.45 g/mol
Synonyms	BMS-708163; BMS708163; (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-1-methyl-1-oxo-3-(2-(2,2,2-trifluoroacetamido)thiazol-4-yl)propan-2-yl)propanamide; (4S)-4-[[(2S)-2-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxy-acetyl]amino]propanoyl]amino]-5-methyl-2-(2,2,2-trifluoroacetamido)-N-thiazol-4-yl-pentanamide; Avagacestat; γ-secretase inhibitor BMS-708163.
EINECS	Contact for details

Quality Control

Our Avagacestat (BMS-708163) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with high-purity research-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.