Description

4-Chloro-7-Hydroxyquinazolin-6-Yl 2,2-Dimethylpropanoate is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is valued for its role as a critical building block in the synthesis of targeted therapeutic agents, particularly kinase inhibitors. It is essential for research and development laboratories, process chemists, and manufacturers in the global pharmaceutical and biotechnology sectors seeking reliable, high-quality raw materials for complex API synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new therapeutic molecules.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial scaffold in the production of complex, high-value active pharmaceutical ingredients.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale manufacturing for new drug development pipelines.

Basic Information

Product Name	4-Chloro-7-Hydroxyquinazolin-6-Yl 2,2-Dimethylpropanoate
CAS No.	1145671-38-0
Molecular Formula	C₁₄H₁₅ClN₂O₃
Molecular Weight	294.73 g/mol
Synonyms	4-Chloro-7-hydroxyquinazolin-6-yl pivalate; 6-Pivaloyloxy-4-chloro-7-hydroxyquinazoline; 4-Chloro-7-(pivaloyloxy)quinazolin-6-ol; 4-Chloro-7-hydroxy-6-quinazolinyl 2,2-dimethylpropanoate; Pivalic acid 4-chloro-7-hydroxy-6-quinazolinyl ester; 4-Chloro-7-hydroxyquinazolin-6-yl trimethylacetate; 4-Chloro-7-(2,2-dimethylpropanoyloxy)quinazolin-6-ol
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Hydroxyquinazolin-6-Yl 2,2-Dimethylpropanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.