Description

Tr-PEG9 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a triazole (Tr) group and a terminal hydroxyl group, separated by a nine-unit PEG spacer. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific attachment of molecules under mild, copper-free conditions. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced material science to create stable, functionalized conjugates with improved pharmacokinetic properties.

Application

• Bioconjugation and Linker Chemistry: Serves as a versatile heterobifunctional linker for coupling peptides, proteins, antibodies, or small molecule drugs to surfaces, nanoparticles, or other biomolecules.
• ADC (Antibody-Drug Conjugate) Development: Used to construct PEGylated linkers in ADCs, enhancing solubility and stability while modulating the drug-to-antibody ratio (DAR).
• PEGylation Reagent: Acts as a functionalized PEG spacer to modify therapeutic proteins, reducing immunogenicity and extending circulatory half-life.
• Diagnostic Probe Synthesis: Facilitates the attachment of fluorescent dyes, chelators, or targeting ligands to create imaging agents and diagnostic tools.
• Surface Functionalization: Used to modify nanoparticles, quantum dots, or biosensor surfaces with bio-orthogonal functional groups for specific binding.
• Click Chemistry Reagent: The triazole group allows for efficient, copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.
• Hydrogel and Biomaterial Cross-linking: Employed as a cross-linking agent or functional monomer in the synthesis of smart hydrogels and biocompatible polymers.
• Drug Delivery System Design: Incorporated into micelles, liposomes, or polymer-drug conjugates to create controlled-release platforms.

Basic Information

Product Name	Tr-PEG9
CAS No.	1144113-16-5
Molecular Formula	C24H45N3O10
Molecular Weight	535.63 g/mol
Synonyms	1-(2-(2-(2-(2-(2-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl-1H-1,2,3-triazole; Triazole-PEG9-OH; 1H-1,2,3-Triazol-1-yl-PEG9-alcohol; Azide-PEG9-Alcohol (after conversion); Heterobifunctional PEG9 linker; Tr-PEG9-OH; PEG9 Triazole
EINECS	Contact for details

Quality Control

Our Tr-PEG9 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities like residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.