Description

(9H-Fluoren-9-Yl)Methyl (4-(Aminomethyl)Phenyl)Carbamate Hydrochloride is a high-purity, protected amino acid derivative widely used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides a stable, reactive handle for the controlled elongation of peptide chains, ensuring high coupling efficiency and minimal side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology industries developing therapeutic peptides, diagnostic agents, and complex biomolecules.

Application

• As a key Fmoc-protected amino acid precursor for automated solid-phase peptide synthesis (SPPS).
• Incorporation of para-aminomethylphenylalanine (PAM) or similar unnatural amino acids into therapeutic peptide sequences.
• Building block for the synthesis of peptide-drug conjugates (PDCs) and targeted therapeutics.
• Research and development of novel peptide-based vaccines and diagnostic probes.
• Production of custom peptides for biochemical assays and structure-activity relationship (SAR) studies.
• Intermediate in the synthesis of complex organic molecules requiring selective amine protection.
• Material for developing chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methyl (4-(Aminomethyl)Phenyl)Carbamate Hydrochloride
CAS No.	1139884-47-1
Molecular Formula	C23H21ClN2O2
Molecular Weight	392.88 g/mol
Synonyms	Fmoc-Pbf-4-Aminomethyl-L-phenylalanine-OH; Fmoc-4-(Aminomethyl)-L-phenylalanine hydrochloride; N-α-Fmoc-N-ε-4-aminomethyl-L-phenylalanine; Fmoc-Amf-OH·HCl; (9-Fluorenylmethoxycarbonyl)-4-(aminomethyl)-L-phenylalanine hydrochloride; Fmoc-4-(Aminomethyl)Phe-OH·HCl; Fmoc-Phe(4-CH2NH2)-OH hydrochloride; Fmoc-L-4-(Aminomethyl)phenylalanine hydrochloride
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methyl (4-(Aminomethyl)Phenyl)Carbamate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and cGMP-grade standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.