Description

8-Fluoro-5-(Trifluoromethyl)Quinoline is a high-value, multi-functional fluorinated quinoline derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular architecture, featuring both fluorine and trifluoromethyl substituents, is engineered to impart desirable properties such as enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is utilized to create novel active ingredients and sophisticated intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies, leveraging the fluorine effect.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity.
• Material Science Research: Serves as a precursor for functionalized organic materials, including ligands for catalysis and components for organic electronics.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	8-Fluoro-5-(Trifluoromethyl)Quinoline
CAS No.	1133115-99-7
Molecular Formula	C10H5F4N
Molecular Weight	215.15 g/mol
Synonyms	8-Fluoro-5-(trifluoromethyl)quinoline; Quinoline, 8-fluoro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-8-fluoroquinoline; 8-Fluoro-5-trifluoromethylquinoline; 1133115-99-7
EINECS	Contact for details

Quality Control

Every batch of 8-Fluoro-5-(Trifluoromethyl)Quinoline is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.