Description

1-Bromo-3-(tert-Butyl)-2-Methoxy-5-Nitrobenzene is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound is valued for its unique substitution pattern, which provides strategic handles for further functionalization and coupling reactions in complex molecule assembly. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its nitro and bromo groups for structural diversification.
• Ligand & Catalyst Development: Serves as a sophisticated backbone for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and photoactive polymers due to its electron-withdrawing nitro group and steric bulk.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & Industrial R&D: A valuable reagent for methodological studies in cross-coupling reactions and aromatic substitution chemistry.

Basic Information

Product Name	1-Bromo-3-(tert-Butyl)-2-Methoxy-5-Nitrobenzene
CAS No.	1132940-55-6
Molecular Formula	C11H14BrNO3
Molecular Weight	288.14 g/mol
Synonyms	2-Bromo-6-tert-butyl-3-nitroanisole; 3-tert-Butyl-2-methoxy-5-nitro-1-bromobenzene; 1-Bromo-3-tert-butyl-2-methoxy-5-nitrobenzene; 2-Methoxy-6-tert-butyl-3-nitro-1-bromobenzene; 5-Nitro-3-tert-butyl-2-methoxybromobenzene; tert-Butyl(2-methoxy-5-nitro-3-bromophenyl); 3-(tert-Butyl)-2-methoxy-5-nitro-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(tert-Butyl)-2-Methoxy-5-Nitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide material for ICH stability studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.