Description

4-{4-[(tert-Butoxy)Carbonyl]-3-Methylpiperazin-1-Yl}Benzoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a piperazine-benzoic acid core protected by a tert-butoxycarbonyl (Boc) group. This compound is critically important for its role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery. Pharmaceutical research and development organizations require this material for its reliable reactivity and structural integrity, which are essential for constructing sophisticated molecular architectures with high precision.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel small-molecule drugs, particularly in oncology and CNS therapeutic areas.
• Protease Inhibitor Research: Used in the development of protease inhibitors, where the piperazine moiety is a common pharmacophore.
• Kinase Inhibitor Synthesis: Serves as a precursor in the creation of targeted kinase inhibitors for cancer treatment.
• Peptidomimetic Chemistry: Employed in the design and synthesis of peptidomimetics to improve metabolic stability and bioavailability of peptide-based drugs.
• Chemical Biology & Probe Development: Utilized as a scaffold for developing chemical probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis under cGMP conditions.

Basic Information

Product Name	4-{4-[(tert-Butoxy)Carbonyl]-3-Methylpiperazin-1-Yl}Benzoic Acid
CAS No.	1131594-97-2
Molecular Formula	C17H24N2O4
Molecular Weight	320.38 g/mol
Synonyms	4-(4-(tert-Butoxycarbonyl)-3-methylpiperazin-1-yl)benzoic acid; 1-Boc-3-methylpiperazine-4-benzoic acid; 4-(4-Boc-3-methyl-1-piperazinyl)benzoic Acid; 4-[4-(tert-Butoxycarbonyl)-3-methyl-1-piperazinyl]benzoic Acid; 1-(4-Carboxyphenyl)-3-methyl-4-Boc-piperazine; Benzoic acid, 4-[4-[(1,1-dimethylethoxy)carbonyl]-3-methyl-1-piperazinyl]-; 1131594-97-2; Boc-3-Me-Pip-Ph-COOH
EINECS	Contact for details

Quality Control

Our 4-{4-[(tert-Butoxy)Carbonyl]-3-Methylpiperazin-1-Yl}Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate production. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.