Description

1H-Pyrazole-4-Carboxylic Acid, 1-(6-Chloropyridin-2-Yl)-5-(Trifluoromethyl)-, Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazole core substituted with chloropyridinyl and trifluoromethyl groups. This compound is of significant commercial value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in agrochemical and pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the agrochemical and pharmaceutical industries for creating compounds with targeted biological activity.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of modern pesticides and herbicides, leveraging the biological activity of the pyrazole and pyridine motifs.
• Pharmaceutical Research: Serves as a versatile scaffold in medicinal chemistry for the development of new drug candidates, especially in central nervous system (CNS) and anti-inflammatory target areas.
• Chemical Synthesis Building Block: Used in organic synthesis to introduce complex heterocyclic structures into larger molecules for material science or specialty chemical applications.
• Process Chemistry & Scale-Up: Employed in process optimization and kilogram-scale production for clinical trial material synthesis.
• Reference Standard: Utilized as an analytical standard in quality control laboratories to ensure the purity and identity of final API batches.

Basic Information

Product Name	1H-Pyrazole-4-Carboxylic Acid, 1-(6-Chloropyridin-2-Yl)-5-(Trifluoromethyl)-, Ethyl Ester
CAS No.	1128268-00-7
Molecular Formula	C12H9ClF3N3O2
Molecular Weight	319.67 g/mol
Synonyms	Ethyl 1-(6-chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; 1-(6-Chloro-2-pyridyl)-5-trifluoromethyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(6-Chloro-2-pyridinyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(6-Chloropyridin-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-(6-Chloro-2-pyridyl)-5-(trifluoromethyl)pyrazole-4-carboxylic Acid Ethyl Ester; 1128268-00-7
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-4-Carboxylic Acid, 1-(6-Chloropyridin-2-Yl)-5-(Trifluoromethyl)-, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong acids, bases, and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.