Description

2-Boc-Amino-6-Chloro-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine group and a carboxylic acid functionality. This compound is critical for the synthesis of complex molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the production of active pharmaceutical ingredients (APIs) and novel therapeutic candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Protease Inhibitor Research: Used in the development of novel protease inhibitors due to its specific stereochemistry and functional groups.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptidomimetics and other bioactive compounds.
• Chemical Biology Probes: Employed in the creation of specialized probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring a protected tetralin derivative.
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-Boc-Amino-6-Chloro-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid
CAS No.	1123169-52-7
Molecular Formula	C₁₇H₂₀ClNO₄
Molecular Weight	337.80 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-6-chloro-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid; 6-Chloro-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid; 2-Boc-amino-6-chloro-1,2,3,4-tetrahydro-2-naphthoic acid; Boc-6-Cl-Tetralin-2-AA; tert-Butyl (6-chloro-2-carboxy-1,2,3,4-tetrahydronaphthalen-2-yl)carbamate; 2-(Boc-amino)-6-chlorotetralin-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-Boc-Amino-6-Chloro-1,2,3,4-Tetrahydro-Naphthalene-2-Carboxylic Acid is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.