Description

5-(Trifluoromethyl)-1-(3-Fluorophenyl)-1H-Pyrazole-4-Carboxylic Acid is a high-value, multi-fluorinated pyrazole derivative serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both trifluoromethyl and fluorophenyl groups, is engineered to impart desirable properties such as enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Material Science Precursor: Serves as a starting material for creating specialized fluorinated polymers, liquid crystals, or organic electronic materials with unique properties.
• Chemical Biology Probe: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors or receptor modulators.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions for clinical trials.

Basic Information

Product Name	5-(Trifluoromethyl)-1-(3-Fluorophenyl)-1H-Pyrazole-4-Carboxylic Acid
CAS No.	1119489-35-8
Molecular Formula	C11H6F4N2O2
Molecular Weight	274.17 g/mol
Synonyms	1-(3-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid; 5-(Trifluoromethyl)-1-(3-fluorophenyl)-4-pyrazolecarboxylic acid; 3-Fluorophenyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid; 1119489-35-8; 5-Trifluoromethyl-1-(3-fluorophenyl)-1H-pyrazole-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(Trifluoromethyl)-1-(3-Fluorophenyl)-1H-Pyrazole-4-Carboxylic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We support development projects requiring material produced under cGMP guidelines for pre-clinical and clinical stage manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.