Description

6-Fluoro-4-(trifluoromethyl)quinolin-2-amine (97%) is a high-purity, fluorinated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluorine substituents, which are strategically placed to modulate the electronic and steric properties of target molecules, enhancing their biological activity and metabolic stability. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in oncology and CNS disorders.
• Kinase Inhibitor Scaffold: Used to construct core structures for potential protein kinase inhibitors due to the quinoline pharmacophore.
• Agrochemical Synthesis: Serves as a precursor in creating new-generation pesticides and herbicides with improved efficacy and environmental profile.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as ligands for catalysts or components for organic electronics.
• Fluorine Chemistry Studies: Utilized as a model compound in academic and industrial research to study the effects of polyfluorination on molecular properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	6-Fluoro-4-(trifluoromethyl)quinolin-2-amine (97%)
CAS No.	1116339-59-3
Molecular Formula	C₁₀H₆F₄N₂
Molecular Weight	230.16 g/mol
Synonyms	2-Amino-6-fluoro-4-(trifluoromethyl)quinoline; 6-Fluoro-4-(trifluoromethyl)-2-quinolinamine; 4-(Trifluoromethyl)-6-fluoroquinolin-2-amine; 1116339-59-3; 6-Fluoro-4-trifluoromethylquinolin-2-ylamine; 2-Quinolinamine, 6-fluoro-4-(trifluoromethyl)-; 6-Fluoro-4-(trifluoromethyl)-2-aminoquinoline
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4-(trifluoromethyl)quinolin-2-amine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.