Description

2-(3-(Methoxycarbonyl)Bicyclo[1.1.1]Pentan-1-Yl)Acetic Acid is a high-value, synthetically challenging bicyclic[1.1.1]pentane (BCP) derivative that serves as a critical building block in modern medicinal chemistry. Its rigid, three-dimensional structure and sp3-rich character are essential for improving the drug-like properties of new therapeutic candidates, particularly in fragment-based drug discovery. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel small molecule drugs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key precursor for incorporating the bicyclo[1.1.1]pentane bioisostere into drug molecules, replacing linear alkynes or aromatic rings to enhance metabolic stability, solubility, and reduce planarity.
• Medicinal Chemistry & Drug Discovery: Used in fragment-based screening and lead optimization campaigns to explore novel chemical space and improve the pharmacokinetic profile of preclinical candidates.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed as a linker or warhead component due to its ability to confer favorable physicochemical properties and three-dimensionality to bifunctional molecules.
• Agrochemical Research: Potential intermediate in the synthesis of novel, structurally advanced active ingredients with improved environmental profiles.
• Material Science: Investigated as a monomer or cross-linking agent for creating polymers with unique thermal and mechanical properties derived from the strained cage structure.
• Academic & Contract Research: Serves as a valuable reagent for methodological development in organic synthesis and for studying the properties of strained hydrocarbon frameworks.

Basic Information

Product Name	2-(3-(Methoxycarbonyl)Bicyclo[1.1.1]Pentan-1-Yl)Acetic Acid
CAS No.	1113001-63-0
Molecular Formula	C10H14O4
Molecular Weight	198.22 g/mol
Synonyms	2-[3-(Methoxycarbonyl)bicyclo[1.1.1]pentan-1-yl]acetic acid; 1-(Carboxymethyl)-3-(methoxycarbonyl)bicyclo[1.1.1]pentane; Methyl 3-(carboxymethyl)bicyclo[1.1.1]pentane-1-carboxylate; BCP-acetic acid derivative; [1.1.1]Propellane acetic acid derivative; Bicyclo[1.1.1]pentane-1-acetic acid, 3-(methoxycarbonyl)-; BCP linker acid
EINECS	Contact for details

Quality Control

Our 2-(3-(Methoxycarbonyl)Bicyclo[1.1.1]Pentan-1-Yl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.