Description

2-Hydroxy-6-(4-Trifluoromethylphenyl)Pyridine is a specialized heterocyclic compound featuring a pyridine core substituted with a hydroxyl group and a trifluoromethylphenyl moiety. This molecular architecture makes it a valuable intermediate or building block in advanced organic synthesis, particularly for applications requiring specific electronic and steric properties. It is primarily utilized by pharmaceutical, agrochemical, and material science research and development teams seeking to develop novel active ingredients or functional materials.

Application

This compound serves as a versatile chemical intermediate with applications across several high-tech industries:

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in developing novel active ingredients for crop protection products, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science Precursor: Acts as a monomer or ligand in the creation of advanced polymers, metal-organic frameworks (MOFs), or organic electronic materials due to its rigid, conjugated structure.
• Chemical Synthesis Reagent: Employed in academic and industrial R&D for constructing complex heterocyclic systems, facilitating Suzuki-Miyaura or other cross-coupling reactions.
• Ligand for Catalysis: Potential use in designing novel catalysts for asymmetric synthesis or other transition metal-catalyzed transformations.

Basic Information

Product Name	2-Hydroxy-6-(4-Trifluoromethylphenyl)Pyridine
CAS No.	1111110-54-3
Molecular Formula	C12H8F3NO
Molecular Weight	239.19 g/mol
Synonyms	6-[4-(Trifluoromethyl)phenyl]pyridin-2-ol; 2-Pyridinol, 6-[4-(trifluoromethyl)phenyl]-; 2-Hydroxy-6-(4-trifluoromethylphenyl)pyridine; 2-Hydroxy-6-(p-trifluoromethylphenyl)pyridine; α,α,α-Trifluoro-p-(6-hydroxy-2-pyridyl)toluene; (4-Trifluoromethylphenyl)-6-hydroxypyridine
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-6-(4-Trifluoromethylphenyl)Pyridine is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from techniques such as HPLC, NMR, and mass spectrometry. Specifications can be tailored to meet the requirements of cGMP or other regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.