Description

1-(4-Chloro-2-Fluoro-6-Hydroxyphenyl)Ethanone is a high-purity, multi-functional aromatic ketone building block of significant importance in advanced organic synthesis. Its unique halogenated phenolic structure makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries seeking to develop new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, anti-inflammatory agents, and antimicrobials.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, where the chloro-fluoro substitution pattern enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Used in the synthesis of specialized fluorinated aromatic cores for electronic materials, contributing to improved performance in display and lighting technologies.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for producing high-performance, halogenated polymers with enhanced flame retardancy and chemical resistance.
• Organic Synthesis & Catalysis Research: A valuable substrate for methodological studies in cross-coupling reactions, fluorination chemistry, and the development of new catalytic systems.
• Dye & Pigment Intermediate: Employed in the synthesis of complex, light-fast dyes and pigments for specialized industrial applications.

Basic Information

Product Name	1-(4-Chloro-2-Fluoro-6-Hydroxyphenyl)Ethanone
CAS No.	1110663-22-3
Molecular Formula	C8H6ClFO2
Molecular Weight	188.58 g/mol
Synonyms	1-(4-Chloro-2-fluoro-6-hydroxyphenyl)ethan-1-one; 4'-Chloro-2'-fluoro-6'-hydroxyacetophenone; 2-Fluoro-4-chloro-6-acetylphenol; 6-Acetyl-3-chloro-5-fluorophenol; 1-Acetyl-3-chloro-5-fluoro-2-hydroxybenzene; 4-Chloro-2-fluoro-6-acetylphenol; CAS 1110663-22-3
EINECS	Contact for details

Quality Control

Our production of 1-(4-Chloro-2-Fluoro-6-Hydroxyphenyl)Ethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Every lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong bases, and acid chlorides. The container should be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.