Description

1-[3-(Difluoromethoxy)Phenyl]Methanamine Hydrochloride is a high-purity, synthetically derived organic compound primarily used as a key pharmaceutical intermediate. Its value lies in its specific difluoromethoxy-substituted aromatic structure, which is crucial for modulating the biological activity and metabolic stability of target drug molecules. This intermediate is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, particularly those developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disorder research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the difluoromethoxy group can enhance compound efficacy and environmental profile.
• Chemical Research & Development: Serves as a versatile precursor for further functionalization in medicinal chemistry and material science projects.
• Ligand and Catalyst Development: The amine hydrochloride functionality makes it suitable for creating specialized ligands for metal catalysis or as a salt form for purification.

Basic Information

Product Name	1-[3-(Difluoromethoxy)Phenyl]Methanamine Hydrochloride
CAS No.	1106917-71-8
Molecular Formula	C9H10ClF2NO
Molecular Weight	221.63 g/mol
Synonyms	1-[3-(Difluoromethoxy)phenyl]methanamine hydrochloride; [3-(Difluoromethoxy)phenyl]methanamine hydrochloride; 3-(Difluoromethoxy)benzylamine hydrochloride; (3-(Difluoromethoxy)phenyl)methanamine HCl; Benzenemethanamine, 3-(difluoromethoxy)-, hydrochloride; 1-(3-(Difluoromethoxyphenyl))methanamine HCl; α-Amino-3-(difluoromethoxy)toluene hydrochloride
EINECS	Contact for details

Quality Control

Our 1-[3-(Difluoromethoxy)Phenyl]Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.