Description

3-Quinolinepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]- is a specialized Fmoc-protected amino acid derivative, a key building block in modern synthetic chemistry. Its primary value lies in enabling the controlled synthesis of complex peptides and peptidomimetics, particularly those incorporating quinoline-based structures for enhanced biological activity. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require reliable, high-quality reagents for solid-phase peptide synthesis (SPPS) and other sophisticated organic transformations.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Solid-Phase Peptide Synthesis (SPPS): Used as a protected amino acid derivative for the controlled, sequential assembly of peptides on resin supports.
• Peptidomimetic Research: Enables the creation of non-natural peptide analogs with improved stability, bioavailability, or target specificity, often for oncology and metabolic disease targets.
• Agrochemical Development: Serves as a precursor for designing novel bioactive compounds with potential herbicidal or insecticidal properties.
• Chemical Biology & Proteomics: Utilized in the synthesis of probes, inhibitors, and labeled peptides for studying protein-protein interactions and enzyme function.
• Material Science: Potential monomer for creating specialized polymers with unique optical or electronic properties derived from the quinoline moiety.

Basic Information

Product Name	3-Quinolinepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-
CAS No.	1106706-63-1
Molecular Formula	C₂₇H₂₄N₂O₄
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-3-(2-quinolyl)-L-alanine; Fmoc-3-(quinolin-2-yl)-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(quinolin-2-yl)propanoic acid; N-α-Fmoc-3-(2-quinolyl)-L-alanine; Fmoc-L-3-(2-quinolyl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(2-quinolinyl)-L-alanine; Fmoc-2-Quinolyl-L-alanine; Fmoc-3-(2-Quinolyl)alanine
EINECS	Contact for details

Quality Control

Our 3-Quinolinepropanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and chiral integrity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere or with desiccant for long-term preservation to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.