Description

2,5-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 6,8-Dioxo-, 1,1-Dimethylethyl Ester is a high-value, protected spirocyclic amino acid derivative used as a sophisticated building block in advanced organic synthesis. Its rigid, three-dimensional spirocyclic scaffold is crucial for constructing complex molecular architectures with precise stereochemistry and enhanced pharmacological properties. This compound is primarily sought after by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring constrained peptide mimetics and heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially protease inhibitors and receptor modulators.
• Peptidomimetic Research: Used to create conformationally restricted peptide analogs, improving metabolic stability and binding affinity in drug discovery.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds and probes to study enzyme function and biological pathways.
• Agrochemical Synthesis: Potential intermediate in the research and development of advanced herbicides or fungicides with novel modes of action.
• Material Science: Can be utilized in the synthesis of specialized polymers or ligands for catalysis and material applications.

Basic Information

Product Name	2,5-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 6,8-Dioxo-, 1,1-Dimethylethyl Ester
CAS No.	1105662-95-0
Molecular Formula	C12H18N2O4
Molecular Weight	254.28 g/mol
Synonyms	tert-Butyl 2,5-diazaspiro[3.5]nonane-2,6,8-trione-5-carboxylate; 1,1-Dimethylethyl 2,5-diazaspiro[3.5]nonane-2,6,8-trione-5-carboxylate; Boc-Protected 2,5-Diazaspiro[3.5]nonane-2,6,8-trione; 5-(tert-Butoxycarbonyl)-2,5-diazaspiro[3.5]nonane-2,6,8-trione; Spirocyclic Hydantoin Boc Derivative; CAS 1105662-95-0; Amino Acid Spirocycle Building Block
EINECS	Contact for details

Quality Control

Our production of 2,5-Diazaspiro[3.5]Nonane-2-Carboxylic Acid, 6,8-Dioxo-, 1,1-Dimethylethyl Ester adheres to strict quality management protocols. Each batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our facility operates under cGMP principles suitable for the production of pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.