Description

(2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate Hydrochloride is a high-purity chiral piperidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in providing a stereochemically defined scaffold essential for constructing complex molecules with high biological specificity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially protease inhibitors and receptor modulators.
• Asymmetric Synthesis: Used as a precursor or catalyst ligand in stereoselective reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Peptidomimetics Development: The hydroxypiperidine carboxylate structure is valuable for designing peptide analogs with improved metabolic stability.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	(2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate Hydrochloride
CAS No.	1104460-09-4
Molecular Formula	C7H14ClNO3
Molecular Weight	195.65 g/mol
Synonyms	Methyl (2R,4R)-4-hydroxypiperidine-2-carboxylate hydrochloride; (2R,4R)-4-Hydroxy-2-piperidinecarboxylic acid methyl ester hydrochloride; (2R,4R)-Methyl 4-hydroxypiperidine-2-carboxylate HCl; (2R,4R)-4-Hydroxypipecolic acid methyl ester hydrochloride; (2R,4R)-HOPC-O-Me•HCl; (2R,4R)-4-Hydroxy-L-pipecolate methyl ester hydrochloride; Methyl (2R,4R)-4-hydroxy-2-piperidinecarboxylate hydrochloride
EINECS	Contact for details

Quality Control

Our (2R,4R)-Methyl 4-Hydroxypiperidine-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment and opened under dry, inert conditions to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.