Description

6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester is a sophisticated, high-purity organic building block featuring a unique spirocyclic and heterocyclic architecture. This compound is of significant value in advanced pharmaceutical research and development, serving as a critical intermediate for constructing complex molecular scaffolds. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of complex drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Protease Inhibitor Synthesis: Used in the construction of molecular frameworks targeting various protease enzymes.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities (NCEs) due to its constrained spirocyclic structure.
• Peptidomimetic Development: Serves as a non-natural amino acid analog for creating stable peptide mimics with enhanced pharmacological properties.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying biological pathways and target validation.
• Process Chemistry & Scale-up: Supplied for route scouting, optimization, and pilot-scale production under current Good Manufacturing Practice (cGMP) guidelines where required.

Basic Information

Product Name	6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester
CAS No.	1101840-72-5
Molecular Formula	C12H21NO3
Molecular Weight	227.30 g/mol
Synonyms	tert-Butyl 4-hydroxy-6-azaspiro[2.5]octane-6-carboxylate; 6-(tert-Butoxycarbonyl)-4-hydroxy-6-azaspiro[2.5]octane; 4-Hydroxy-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; Boc-4-hydroxy-6-azaspiro[2.5]octane; 6-Boc-4-hydroxy-6-azaspiro[2.5]octane; (4-Hydroxy-6-azaspiro[2.5]octan-6-yl)(tert-butoxy)methanone
EINECS	Contact for details

Quality Control

Our production of 6-Azaspiro[2.5]Octane-6-Carboxylic Acid, 4-Hydroxy-, 1,1-Dimethylethyl Ester adheres to stringent quality protocols suitable for research and pharmaceutical applications. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment. We support development projects requiring material produced under cGMP guidelines and can provide relevant documentation packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; therefore, containers should be kept tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.