Description

2-Bromo-6-(Trifluoromethyl) Quinoline is a high-value, multi-functional heterocyclic building block distinguished by its bromine and trifluoromethyl substituents. This compound is essential for facilitating advanced molecular transformations in synthetic chemistry, offering a strategic combination of reactivity and lipophilicity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a critical scaffold for developing new-generation herbicides and fungicides with enhanced efficacy and environmental profiles.
• Material Science: Used in the creation of advanced organic electronic materials, including OLEDs and charge-transport molecules, due to its electron-deficient quinoline core.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Buchwald-Hartwig aminations for carbon-carbon and carbon-heteroatom bond formation.
• Ligand Synthesis: Employed in the development of novel nitrogen-containing ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: The trifluoromethyl group provides a valuable handle for studying the effects of fluorine incorporation on biological activity and material properties.

Basic Information

Product Name	2-Bromo-6-(Trifluoromethyl) Quinoline
CAS No.	1101205-26-8
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	6-(Trifluoromethyl)-2-bromoquinoline; 2-Bromo-6-trifluoromethylquinoline; Quinoline, 2-bromo-6-(trifluoromethyl)-; 2-Bromo-6-(trifluoromethyl)quinoline; 2-Brom-6-(trifluormethyl)chinolin (German); 2-ブロモ-6-(トリフルオロメチル)キノリン (Japanese)
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-(Trifluoromethyl) Quinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.