Description

5-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One is a versatile brominated isoquinolinone derivative, a key synthetic intermediate prized for its unique heterocyclic scaffold and reactive bromine substituent. This compound is critical for researchers and manufacturers requiring a high-purity building block to construct complex molecules for pharmaceutical and agrochemical discovery. It is primarily utilized by R&D chemists and process development teams in the life sciences sector for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Synthesis: The reactive bromine atom enables further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for library synthesis.
• Material Science: Acts as a monomer or functional additive in the development of advanced polymers and organic electronic materials.
• Academic & Contract Research: Essential for medicinal chemistry programs and methodological studies in universities and CROs (Contract Research Organizations).

Basic Information

Product Name	5-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1100509-38-3
Molecular Formula	C10H10BrNO
Molecular Weight	240.10 g/mol
Synonyms	5-Bromo-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-one; 5-Bromo-2-methyl-3,4-dihydro-1H-isoquinolin-1-one; 2-Methyl-5-bromo-3,4-dihydroisoquinolin-1(2H)-one; 5-Bromo-2-methyl-1-oxo-1,2,3,4-tetrahydroisoquinoline; 1100509-38-3
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Methyl-3,4-Dihydroisoquinolin-1(2H)-One is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.